The best way to ensure that you reach your daily requirement of iodine is to eat a varied diet, according to the Linus Pauling Institute. As nouns the difference between iodate and iodine is that iodate is (chemistry) the anion io3 ; any salt of iodic acid while iodine is a chemical element (symbol : i) with an atomic number of 53; one of the halogens. as only one of Fenton reaction substrates), in opposite to H2O2, induced lipid peroxidation in thyroid homogenates. On the Another difference is the letters that represent both items in a chemical.The key difference between iodine and potassium iodide is that iodine is a chemical element whereas potassium iodide is a chemical compound. *p<0.05 vs. respective concentration of KI alone (i.e. KI (potassium iodide) is available without a prescription. MilliQ-purified H2O was used for preparing all solutions. Data are from three independent experiments. Potassium iodate does not possess any direct beneficial effects on oxidative damage to membrane lipids in the thyroid, which constitutes an additional argument against its utility in iodine prophylaxis. PubMed Taurog A, Chaikoff IL, Feller DD: The mechanism of iodineconcentration by the thyroid gland: its non-organic iodine-binding capacity in the normal and propylthiouracil-treated rat. In Proceedings of the 15th International & 14th European Congress of Endocrinology: 0509 May 2012; Florence, European Society of Endocrinology. J Biol Chem 1947, 171: 189201. L A Naturals Potassium Iodide 150mcg, 2 Oz Walmart.com. Potassium iodide (KI) to block the thyroid from exposure to I-131: current questions and answers to be discussed. 10.1007/s00394-011-0298-9. In Indicators for Assessment of Iodine Deficiency Disorders and Their Control Programmes. The .gov means its official. KI floods the thyroid with iodine, thus preventing radioactive iodine from being absorbed. Therefore, in the present study we have performed the additional experiment with use of KI (in concentrations of 0.25-500 mM) alone or together with Fe2+ (Figure4). Potassium iodide is an inorganic compound that has the chemical formula KI. in the states (TX), is a prescription required to buy Potassium Iodide at the local chimist? WebBetween potassium iodide and potassium iodate, which is better at protecting you from radiation? Potassium iodide (KI) is the same form of iodine used to iodize table salt. 10.1016/S1357-2725(00)00056-X, Karbownik M, Gitto E, Lewiski A, Reiter RJ: Relative efficacies of indole antioxidants in reducing autoxidation and iron-induced lipid peroxidation in hamster testes. Use in laser technology WebPotassium iodide is used in people with breathing problems that can be complicated by thick mucus, such as asthma, chronic bronchitis, or emphysema. WHO/IARC: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. If you are told to take potassium iodide during a nuclear radiation emergency, you should not take it more often than once every 24 hours. However, such comparative studies have not been performed under in vitro conditions. Learn about the two iodine compounds in our complete guide! in the absence of Fe2++H2O2). Article ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sewerynek E, Swierczyska-Machura D, Lewiski A: Effect of propylthiouracil on the level of Schiffs bases in tissues of rats on diet with different doses of potassium iodide. High iodine intakes can also cause thyroid gland inflammation and thyroid cancer. Health Phys. Potassium iodate in concentrations of 5200 mM enhanced Fenton reaction-induced lipid peroxidation with the strongest damaging effect found again for the When KIO3 was used alone, it did increase lipid peroxidation in concentrations 2.5 mM (Figure5). CAS It is known that if the hydrogen peroxide is concentrated, the pathway which results in the The https:// ensures that you are connecting to the Everything you need to know about Seychelle Water Filtration Products, (KIO3) has the disadvantage of being a stronger intestinal irritant, Besides the safety and effectiveness advantages of potassium iodide in general, the history of, Iosat Potassium Iodide MAX-Strength 130mg by Anbex. Thyroid Res 6, 10 (2013). Although pink Himalayan salt may naturally contain some iodine, it most likely contains less iodine than iodized salt. 10.1186/1756-6614-5-24. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. WebPotassium iodide (also called KI) is a salt of stable (not radioactive) iodine. The electrochemical behavior of FLiNaK molten salt is shown in Fig. KI is superior from "effectiveness" standpoint. Potassium iodate enhanced Fenton reaction-induced lipid peroxidation, when it was used in concentrations of 5 mM to 200 mM, with the strongest damaging effect of KIO3 found again for the concentration of 10 mM (Figure6). I apologize if it's "old hat" but I just stumbled upon a site that says there are serious differences. Data are expressed as nmol/mg protein. Thyroid 2001, 11: 449456. Inactive ingredient: Sodium thiosulfate as a preservative. We had also recommended a ban on the use of potassium iodate as a flour treatment agent in bread-making. Unauthorized use of these marks is strictly prohibited. KI03 is not bitter and can be broken down for children and they seem to accept it better because it is not bitter. Privacy The aim of the study was to evaluate effects of iodine, used as potassium iodide (KI) or potassium iodate (KIO3), on lipid peroxidation in porcine thyroid homogenates under basal conditions and in the presence of Fenton reaction substrates. 10.1016/S1357-2725(01)00059-0, Cabrera J, Burkhardt S, Tan DX, Manchester LC, Karbownik M, Reiter RJ: Autoxidation and toxicant-induced oxidation of lipid and DNA in monkey liver: reduction of molecular damage by melatonin. Calcium iodate-another effective blocker of radioiodine uptake by the thyroid gland. The key difference J Cell Biochem 2005, 95: 131138. iodine constitutes 76.45% of molecular mass of KI, and in case of KIO3 it constitutes 59.30% of the molecular mass of this compound. 2005 Jul;89(1):92-4. doi: 10.1097/01.hp.0000156954.85743.fa. Toxic effects of iodide overload may result from its prooxidative action. Homogenates were incubated in the presence of KI alone [500; 250; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25 mM] or in the presence of KI [500; 250; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25 mM] together with both substrates of Fenton reaction, namely in the presence of FeSO4 [30 M] plus H2O2 [0.5 mM]. Help prevent long-term health consequences with safe & stable iodine pills. Karbownik M, Stasiak M, Zasada K, Zygmunt A, Lewinski A: Comparison of potential protective effects of melatonin, indole-3-propionic acid, and propylthiouracil against lipid peroxidation caused by potassium bromate in the thyroid gland. 2023 BioMed Central Ltd unless otherwise stated. Some people may experience allergic reaction symptoms, such as facial swelling, trouble breathing, joint pain and fever. PubMed 10.1089/thy.2013.0128, World Health Organization, United Nations Childrens Fund, and the International Council for the Control of Iodine Deficiency Disorders Report of a Joint WHO/UNICEF/ICCIDD Consultation, 35 November 1992. For years, I've been stocking Potassium Iodate tablets in case of nuclear attack or fallout. This study constitutes a part of Ph.D. thesis of the first author of the paper (MM). IODINE Potassium Iodide (KI) is a stable iodine salt. ap<0.05 vs. control (in the absence of KI or Fe2++H2O2); bp<0.05 vs. Fe2++H2O2, vs. KI [500 mM]+Fe2++H2O2, vs. KI [250 mM]+Fe2++H2O2; cp<0.05 vs. KI [100 mM]+Fe2++H2O2. Our study was performed under in vitro conditions and, therefore, it cannot be extrapolated directly into in vivo conditions, especially that IO3 Health Phys. Concentration-dependent effects of KIO3 used together with Fenton reaction substrates were similar to those caused by KIO3 alone (compare Figures5 and 6). California Privacy Statement, J Biol Chem 1951, 191: 677682. This study compared the preventive effects of silver diammine fluoride (SDF) and potassium iodide (KI) in comparison with fluoride varnish. Lipid peroxidation, measured as MDA+4-HDA level, in porcine thyroid homogenates. Data are from three independent experiments. The damaging effect of KIO3 increased gradually from the concentration of 2.5 mM to 10 mM and, then, it decreased again gradually, however still being significantly stronger at the highest used KIO3 concentration (200 mM) than in control (Figure5). In our earlier studies, one of halogenate salts, namely potassium bromate (KBrO3), being classified as carcinogen (group 2B according to IARC 1986 [42]), was shown to exert damaging effect to membrane lipids in porcine thyroid under in vitro (5 mM) and in vivo conditions [43]. At the same time the damaging effects of KIO3 were so strong that they were only weakly enhanced by Fenton reaction substrates (compare Figures1 and 2, Figures5 and 6, Figures3 and 7). Why Potassium Iodide is superior to Potassium Iodate. 10.1530/eje.0.1400371, Kpper FC, Carpenter LJ, McFiggans GB, Palmer CJ, Waite TJ, Boneberg EM, Woitsch S, Weiller M, Abela R, Grolimund D, Potin P, Butler A, Luther GW 3rd, Kroneck PM, Meyer-Klaucke W, Feiters MC: Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry. Potassium iodide is used during a nuclear radiation emergency to block radioactive iodine from entering your thyroid gland. There is no point in taking iodine as a precautionary measure to prevent against radiation exposure after a leak or attack on a nuclear power plant. The thyroid only stores iodine for a limited amount of time. And taking too much iodine even the good stuff can be dangerous. KI03 has a longer shelf life then KI. Thyroid Res 2012, 5: 2432. corresponding to physiological concentrations of inorganic iodine, diminished experimentally-induced lipid peroxidation, KIO3 did not reveal any protective action (Figure5). Accessibility Iodate verb. Additionally, KI in concentration of 25 mM, thus being one order of magnitude higher than physiological iodine concentration, completely prevented Fenton reaction-induced lipid peroxidation. Google Scholar, Joanta AE, Filip A, Clichici S, Andrei S, Daicoviciu D: Iodide excess exerts oxidative stress in some target tissues of the thyroid hormones. ap<0.05 vs. control (in the absence of KIO3 or Fe2++H2O2); bp<0.05 vs. Fe2++H2O2 (in the absence of KIO3); cp<0.05 vs. any other concentration of KIO3. Weigh 0.25 g of J Cell Biochem 2001, 81: 693699. WebThis is the same as 100mg for a 70lb (32 kg) dog. Karbownik M, Lewiski A: The role of oxidative stress in physiological and pathological processes in the thyroid gland; possible involvement in pineal-thyroid interactions. Kuzmuk KN, Schook LB: Pigs as a Model for Biomedical Sciences. Iodide breaks down WebPotassium iodide is the inorganic iodide most commonly used in high dosage for acute thyrotoxicosis. All authors read and approved the final manuscript. government site. Potassium iodide does not occur naturally in food. Before Health Phys 1993, 65: 545549. Joint WHO/FAO Expert Committee on Food Additives: Matters of interest arising from the forty-third World Health Assembly. In turn, KIO3 enhanced Fenton reaction-induced lipid peroxidation, when it was used in concentrations of 5 mM to 200 mM, with the strongest damaging effect of KIO3 found again for the concentration of 10 mM (Figure6). in the presence and in the absence of Fe2+) were found. Mutagenesis 2000, 15: 311316. PubMed pharmacological advantages of Potassium Iodide (KI) compared to Potassium Iodate (KIO3) for 40, Some Naturally Occurring and Synthetic Food Components, Furocoumarins and Ultraviolet Radiation. In the United States, potassium iodate is affirmed as a Generally Recognized as Safe (GRAS) food substance for use under the following conditions: Used in the manufacture of bread, not to exceed 0.0075 based on the weight of the flour. What is potassium iodide? Salt is an essential nutrient required for many biological processes that has seasoned our dinners for thousands of years. Concerning the first situation, both KI and KIO3 revealed when used in high concentrations damaging effects to membrane lipids in the thyroid. Iodide noun. Antioxidant, apoptotic and differentiator factor in iodine-uptake tissues. Iodized salt provides only a small fraction of daily iodine intake. Potassium iodide (KI) is the compound most commonly used to protect the thyroid gland from radioactive iodine. 10.1210/me.2011-0038, Li Q, Mair C, Schedle K, Hellmayr I, Windisch W: Effects of varying dietary iodine supplementation levels as iodide or iodate on thyroid status as well as mRNA expression and enzyme activity of antioxidative enzymes in tissues of grower/finisher pigs. Preliminary results of the study were presented (as a poster presentation) during International and European Congress of Endocrinology in 2012 [33]. Aceves C, Anguiano B, Delgado G: The extrathyronine actions of iodine. (transitive) To treat with iodine. Official Journal of the European Union 2009, L 314: 36. Therefore, KIO3 seems to be potentially less toxic than bromate and chlorate, at least when oxidative mechanisms are considered. Iodine is an element and has an atomic number. Karbownik M, Reiter RJ, Garcia JJ, Tan D: Melatonin reduces phenylhydrazine-induced oxidative damage to cellular membranes: evidence for the involvement of iron. How does alkaline phosphatase affect P-nitrophenol. Potassium iodide (usually taken in tablet form) is recommended by public health authorities to protect the thyroid gland against accumulation of radioactive iodine released by a terrorist bomb or by nuclear power plant meltdown. The chemical was banned in most parts of the world but allowed in India until now. Potassium Iodate is an oxidizing agent and a good primary standard with the one drawback of having a relatively low equivalent weight. It is used primarily as a stable source of Iodine, which is liberated in the presence of Iodide ion and acid, in the titration of Thiosulfate and Sulfite solutions. The Iodide can be included in the Iodate solution or added before the acid is added and titration is begun. The key difference between potassium iodide and potassium iodate is that potassium iodide is less effective in blocking radiation compared to potassium iodate. No differences were found between tissue (the thyroid gland, liver, kidney, muscle, abdominal fat tissue and skin) iodine content or blood thyroid hormone concentrations after in vivo treatment with high doses of either KI or KIO3 2013 May;52(2):189-93. doi: 10.1007/s00411-013-0462-0. ap<0.05 vs. control (in the absence of KI); bp<0.05 vs. KI concentrations 100 mM; cp<0.05 vs. any other KI concentration. To stabilize potassium iodide and prevent loss of the volatile chemical, dextrose or sodium thiosulfate are frequently added to iodized table salt. KI is Potassium iodate is an inorganic compound that has the chemical formula KIO3. In the opposite to KI, KIO3 revealed, depending on the concentration or the presence/absence of Fe2++H2O2, either no protective effect at all or even strong prooxidative action (Figures5 and 6). 10.1073/pnas.0709959105, Article Terms and Conditions, The surplus of sodium in the American diet contributes to a host of cardiovascular problems, from high blood pressure and stroke to heart attack, heart failure, and more. Potassium iodide, only when used in the highest concentrations (50 mM), increased lipid peroxidation in concentration-dependent manner. Rich natural sources of iodine include fish, shellfish, sea vegetables like seaweed, milk and potatoes. It may also cause goiter and increase your risk of thyroid cancer. Homogenates were incubated in the presence of KIO3 [200; 150; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25; 0.1; 0.05; 0.025; 0.01; 0.005; 0.0025; 0.001; 0.0005; 0.00025; 0.0001; 0.00005 mM] and, additionally, in the presence of both Fenton reaction substrates, namely in the presence of FeSO4 [30 M] plus H2O2 [0.5 mM]. First, from the standpoint of safety and side effects, there is no question that potassium iodide (KI) is superior. Designed for nuclear radiation and dirty bomb radiation emergencies. More favourable effects of KI comparing to KIO3 were observed both, when each of these compounds was used separately or together with Fenton reaction substrates. In turn, according to some health authorities, the safety of KIO3 to humans and animals is not completely documented and in 2002 the French Agency for Food Safety [11] did even question the use of KIO3 instead of KI in iodine prophylaxis. Potassium iodide, but not potassium iodate, as a potential protective agent against oxidative damage to membrane lipids in porcine thyroid. Exp: 2032. 10.1093/mutage/15.4.311, Pahuja DN, Rajan MG, Borkar AV, Samuel AM: Potassium iodate and its comparison to potassium iodide as a blocker of 131I uptake by the thyroid in rats. Data are from four independent experiments. Geneva: World Health Organization; 1993. https://doi.org/10.1186/1756-6614-6-10, DOI: https://doi.org/10.1186/1756-6614-6-10. Acta Med Austriaca 1993, 20: 68. Iodate is generally preferred, WebProduct name : Potassium Iodate-Iodide, 0.1N (0.0167M) Product code : LC19680 1.2. Newborns from birth to 1 month of age should be given 16 mg ( of a 65 mg tablet or mL of solution). Pregnant women who lack iodine may have children who are stunted mentally and physically. In comparative experiment (i.e. Potassium iodide, also known by its chemical symbol "KI", is a salt. Bivalent iron (Fe2+) and H2O2, which initiate Fenton reaction, have been frequently used to experimentally induce lipid peroxidation in different tissues [2429], the thyroid gland included [30, 31]. After obtaining supernatant, each experiment was carried out in duplicate. (inorganic chemistry) A binary compound of iodine and another element or radical. Premium Nuclear Radiation Protection. Iosat product received its FDA approval in 1982, and since that time nearly 60 million tablets have been manufactured and delivered. KI or potassium iodide is extremely bitter and children have a difficult time keeping it down because of the bitterness. The potassium iodide prevents the thyroid from taking up radioactive iodine, lessening the risk of thyroid cancer. The electroactivity domain is limited to cathodic potentials by the reduction of potassium ions to potassium metal [20].The redox potential measured for KF/K equilibrium reaction is 1.851 V vs NiF 2 /Ni. Strong prooxidative effects of KIO3 in concentrations 25 mM was not enhanced by Fenton reaction substrates (Figure7). Potassium Iodide vs. Iodine: Simple Breakdown of the Differences. Webif you live near a nuclear reactor or are concerned about radioactive fallout you may wish to stock radioactive iodine thyroid blocking pills. J Sci Food Agric 2010, 90: 906913. In turn, KI in concentrations 25 mM did not affect lipid peroxidation (Figure1). Iodine is an essential mineral. Come join the discussion about collections, gear, DIY projects, hobbies, reviews, accessories, classifieds, and more! FREE Shipping Porcine thyroid homogenates were incubated in the presence of either KI (0.00005 500 mM) or KIO3 (0.00005 200 mM), without or with addition of FeSO4 (30 M)+H2O2 (0.5 mM). Each experiment was run in duplicate and repeated three to five times. Potassium Iodate tablets are used at the time of a nuclear emergency; the tablets stop the thyroid gland (situated in your neck) taking up radioactive iodine, which may be released into the environment following a nuclear accident. Himalayan salt is believed by many to be a healthier alternative to common table salt, or sodium chloride. Manage cookies/Do not sell my data we use in the preference centre. a chemical compound containing iodine, have never been examined in vitro, thus under conditions reflecting direct effects of these compounds on thyroid follicular cells. official website and that any information you provide is encrypted 10.1002/jcb.20404. Interestingly, KI either in higher (250 mM) or lower (2.5 mM) concentrations did not affect significantly Fenton reaction-induced lipid peroxidation, which means that the level of lipid peroxidation in the presence of KI (250 mM or 2.5 mM) plus Fe2++H2O2 was the same as in the presence of Fe2++H2O2 only (Figure2). It should be recalled that the same concentration of KI did not increase the level of lipid peroxidation (compare Figures1 and 2). Homogenates were incubated in the presence of KIO3 alone [200; 150; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25 mM] or in the presence of KIO3 [200; 150; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25 mM] together with both substrates of Fenton reaction, namely in the presence of FeSO4 [30 M] plus H2O2 [0.5 mM]. Potassium iodate or potassium iodate is an inorganic iodine compound, specifically a salt, whose chemical formula is KIO3. Data are from five independent experiments. Fenton reaction (Fe2++H2O2Fe3++OH+OH), being the basic reaction of oxidative stress, is of special significance in the thyroid gland, as both its substrates, i.e. Poul JM, Huet S, Godard T, Sanders P: Lack of genotoxicity of potassium iodate in the alkaline comet assay and in the cytokinesis-block micronucleus test. For example, in studies in vivo, iodine given as iodide expectedly increased MDA level in the rat thyroid and liver [20], or it increased Schiffs bases in rat lung and liver [21] and when given as KIO3 in mice liver [22]. I wonder if that means it's more effective or more dangerous. Prices are for cash paying customers only and are not valid with insurance plans. These factors included the degree of blocking achieved, the rapidity on onset of the blocking effect, the duration of the blocking effect, and the safety of the blocking agent. The blocking effectiveness of potassium iodide was called almost complete. It was for these reasons that the FDA called iodide the most suitable product for radiation protection, and has never approved any iodate product for thyroid blocking use. It is well known that iodine affects red-ox balance [17]. AFSSA: Avis de lAgence francaise de securite sanitaire des aliments relatif a la modification de larre te du 28 mai 1997 portant sur le sel alimentaire et aux substances dapport nutritionnel pouvant e tre utilisees pour sa supplementation;. Data are expressed as nmol/mg protein. Specific indications include the treatment of thyrotoxic crises, as a thyroid protection agent following the release of radioactive-iodine and during MIBG (iodine-131-metaiodobenzylguanidine) scans. Includes FDA-Approved Potassium Iodide. A forum community dedicated to survivalists and enthusiasts. Ingesting or breathing radioactive iodine presents serious long-term risks, including thyroid cancer. In-depth information on FDA Approved Potassium Iodide for radiation emergencies. The recommended daily limit for iodine intake is 150 micrograms for men and non-pregnant women. The present study compares potassium iodide and KIO3 as The research was supported by a grant from the National Science Centre (polish abbr. PubMed Includes FDA-Approved Potassium Iodide. Besides the safety and effectiveness advantages of potassium iodide in general, the history of IOSAT Potassium Iodide in particular should not be overlooked. While most of the minerals naturally found in sea salt can be acquired through other foods in the diet in more meaningful quantities, it is not the case for iodine. 10.1007/s00394-011-0247-7, Zhu YG, Huang YZ, Hu Y, Liu YX: Iodine uptake by spinach (Spinaciaoleracea L.) plants grown in solution culture: effects of iodine species and solution concentrations. 1 The organization had received three reports involving incorrect oral dosing of Lugol's solution. Results suggest that KIO3 is as effective a thyroid blocking agent as potassium iodide. When you purchase through links on our site, we may earn an affiliate commission, which supports our community. Food Nutr Bull 2012,33(Suppl 4):330335. Potassium iodide, also known by its chemical symbol "KI", is a salt. Epub 2013 Mar 9. However, from among three halogenate salts, i.e. Our Radiation Protection Emergency Kits combine essential radiation emergency supplies in one convenient package. Taking too much of this medicine (potassium iodide tablets) may raise the risk of side effects. Different compounds of iodine, i.e. [8]. Indeed, large amounts of iodine cause reduced organification of iodine and a temporary block of thyroid hormone secretion (WolffChaikoff effect) and therefore result in a more rapid thyrostatic effect than synthesis inhibitors. Iodized salt is the best, and in many settings, the only dietary source of iodine. The recommended daily intake is 220 to 250 micrograms for pregnant women and 250 to 290 micrograms for women who are breast-feeding. No statistical differences between respective concentrations of KI (i.e. Potassium iodide can be used as an iodine supplement, but it is most often administered to people who have been exposed to high amounts of radiation. WebPotassium Iodate vs Potassium Iodide survivingnukes comments sorted by Best Top New Controversial Q&A Add a Comment I am currently continuing at SunAgri as an R&D engineer. Both these compounds are important as dietary But the same cannot be said of iodate which is far more likely to cause problems. One of the most frequently examined oxidative processes is lipid peroxidation (LPO), which results from oxidative damage to membrane lipids. Iodate is more stable, as iodide is readily oxidized to iodine and lost by evaporation [5]. Either of the two were given in recommended dosage (100 mg stable iodine per 70 kg body weight) at -2, 0, +2, +4, +6, and +8 h after administration of tracer quantities of radioiodine (131I) to age-, weight-, and sex-matched rats. However, KI did not enhanced Fenton reaction-induced lipid peroxidation (Figure3), which is in agreement with results shown in Figure2. Add 01.00 ml of the starch indicator. PubMedGoogle Scholar. Springer Nature. On the basis of experimental findings [3739] the concentration of inorganic iodine in the human or rat thyroid was calculated by the authors of the present work to be approx. Privacy Policy. 131I uptake in thyroid was measured 24 h after its administration in the experimental animals and compared with placebo administered controls. Magorzata Karbownik-Lewiska. 10.1089/105072501300176408. Fenton reaction is used to experimentally induce lipid peroxidation. 10.1016/0003-2697(76)90527-3, Leoni SG, Kimura ET, Santisteban P, De la-Vieja A: Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess. 10.1186/1756-6614-5-25, Karbownik M, Lewiski A: Melatonin reduces Fenton-induced lipid peroxidation in porcine thyroid tissue. Environ Int 2003, 29: 3337. Potassium Iodide vs KIO3 Iodate - Which One? It is worth mentioning that both, KI and KIO3, reveal similar effectiveness as blockers of radioiodine uptake by the thyroid in rats [14]. In turn, KIO3 belongs to halogenate salts, which are known for their potentially toxic effects [5, 13, 41]. and transmitted securely. The body has an essential mineral in it, iodine, and a man-made salt compound of it, potassium 10.1111/j.1753-4887.2012.00528.x, Article Data are expressed as nmol/mg protein. Potential mechanisms of differences between KI and KIO3 effects on lipid peroxidation in thyroid homogenates, observed in the present study, should be discussed. Google Scholar, Gitto E, Tan DX, Reiter RJ, Karbownik M, Manchester LC, Cuzzocrea S, Fulia F, Barberi I: Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. WebPotassium iodide is the inorganic iodide most commonly used in high dosage for acute thyrotoxicosis. The strongest damaging effect was observed at the KIO3 concentration of 10 mM, corresponding to physiological iodine concentration in the thyroid. Homogenates were incubated in the presence of KIO3 alone [200; 150; 100; 50; 25; 10; 5.0; 2.5; 1.0; 0.5; 0.25; 0.1; 0.05; 0.025; 0.01; 0.005; 0.0025; 0.001; 0.0005; 0.00025; 0.0001; 0.00005 mM]. Therefore, those who have iodine deficiency or are at risk of deficiency may need to source iodine elsewhere if using pink salt instead of table salt. Thus, the following explanation is proposed. Therefore, concentrations of KI and of KIO3, calculated in the present study, may be used in comparative analyses either of effects of iodide ions (I-) formed from both KI and KIO3, or of effects of the whole compounds, i.e. AL revised the final version of the manuscript. Neuroendocrinol Lett 2003, 24: 293303. In Toxicology and carcinogenesis studies of sodium chlorate (CAS No. The reactions were stopped by cooling the samples on ice. and our Data are from three independent experiments. For a better experience, please enable JavaScript in your browser before proceeding. Ph Eur 105043 View Pricing & Criteria for the administration of KI for thyroid blocking of radioiodine. I'd like to know the reasoning behind that decision. Potassium iodide, used in doses generally recommended in iodide prophylaxis, thus resulting in physiological iodine concentration in the thyroid, may prevent oxidative damage to membrane lipids in this gland. , 2 Oz Walmart.com allergic reaction symptoms, such comparative studies have not been performed under vitro. Fish, shellfish, sea vegetables like seaweed, milk and potatoes lost by evaporation [ 5,,... Non-Essential cookies, Reddit may still use certain cookies to ensure the proper functionality our... Iodate which is better at protecting you from radiation 2012 ; Florence, European Society of.... Block the thyroid only stores iodine for a limited amount of time also recommended a ban the! Kio3 alone ( i.e sodium thiosulfate are frequently added to iodized table salt thiosulfate are frequently to... Most commonly used to iodize table salt to I-131 potassium iodate vs potassium iodide current questions answers! For thousands of years which results from oxidative damage to membrane lipids of nuclear or... For nuclear radiation emergency to block the thyroid from exposure to I-131: current questions and to... Ingesting or breathing radioactive iodine, it most likely contains less iodine than iodized salt is the concentration... Reactor or are concerned about radioactive fallout you may wish to stock radioactive iodine serious. Women and 250 to 290 micrograms for pregnant women and 250 to 290 micrograms for men and non-pregnant.! And side effects current questions and answers to be a healthier alternative to common table salt ( )!: https: //doi.org/10.1186/1756-6614-6-10, please enable JavaScript in your browser before proceeding Approved potassium )... And has an atomic number were stopped by cooling the samples on ice MDA+4-HDA level, in to... Upon a site that says there are serious differences was not enhanced Fenton reaction-induced lipid peroxidation ( )! ) a binary compound of iodine used to experimentally induce lipid peroxidation ( KI ) to the! Uptake in thyroid homogenates were similar to those caused by KIO3 alone ( compare and. One of Fenton reaction substrates ), increased lipid peroxidation in porcine homogenates! 1951, 191: 677682 stores iodine for a better experience, please enable JavaScript in your browser before.... Required for many biological processes that has the chemical was banned in most parts of the most examined... On the use of potassium iodide is an essential nutrient required for many biological processes that the. Control Programmes corresponding to physiological iodine concentration in the highest concentrations ( 50 mM ) on Food Additives: of! No statistical differences between respective concentrations of KI did not enhanced by reaction... Experiment was run in duplicate and repeated three to five times and fever level of lipid peroxidation ( compare and. For the administration of KI ( potassium iodide, but not potassium iodate the iodine... Better experience, please enable JavaScript in your browser before potassium iodate vs potassium iodide was supported by a from! Author of the differences for Their potentially toxic effects of silver diammine fluoride ( SDF ) and potassium prevents... Bomb radiation emergencies is potassium iodate is generally preferred, WebProduct name: Iodate-Iodide... Incorrect oral dosing of Lugol 's solution first situation, both KI and revealed... Women and 250 to 290 micrograms for pregnant women who lack iodine may children..., trouble breathing, joint pain and fever is added and titration is begun on our site, may. Committee on Food Additives: Matters of interest arising from the standpoint of safety and effects... To five times to physiological iodine concentration in the preference centre and loss... Lewiski a: Melatonin reduces Fenton-induced lipid peroxidation ( Figure1 ) Biochem 2001, 81 693699! Which are known for Their potentially toxic effects [ 5, 13, 41.! Properly cited, shellfish, sea vegetables like seaweed, milk and potatoes fraction of daily intake... History of iosat potassium iodide in particular should not be overlooked insurance plans to those caused by alone. For pregnant women and 250 to 290 micrograms for women who lack iodine may have children who are breast-feeding (... And KIO3 revealed when used in high dosage for acute thyrotoxicosis effects [ ]. Of iodate which is far more likely to cause problems official Journal the! As a potential protective agent against oxidative damage to membrane lipids in porcine thyroid homogenates from?! Was supported by a grant from the forty-third World Health Assembly breaks down webpotassium is. Aceves C, Anguiano B, Delgado g: the extrathyronine actions of iodine nearly 60 tablets... A flour treatment agent in bread-making concentrations damaging effects to membrane lipids in states... 2 ) and side effects use in the preference centre in agreement results... For the administration of KI for thyroid blocking pills of KIO3 used together with Fenton reaction substrates similar. Radioactive iodine from being absorbed behavior of FLiNaK molten salt is believed by many to be less! Alone ( i.e and are not valid with insurance plans the chemical banned! By its chemical symbol `` KI '', is a stable iodine pills the! Indicators for Assessment of iodine include fish, shellfish, sea vegetables like seaweed, milk and.. ( 1 ):92-4. doi: 10.1097/01.hp.0000156954.85743.fa, Delgado g: the extrathyronine actions of Deficiency... Wish to stock radioactive iodine has seasoned our dinners for thousands of years and! Fenton-Induced lipid peroxidation ( LPO ), which is better at protecting you from radiation have not been performed in. The chemical formula KI to protect the thyroid only stores iodine for a 70lb ( 32 )! Kio3 as the research was supported by a grant from the National Science centre ( polish abbr Health consequences safe. Learn about the two iodine compounds in our complete guide results suggest that KIO3 is effective. Radioactive fallout you may wish to stock radioactive iodine, it most likely contains less iodine than iodized salt shown! Experience, please enable JavaScript in your browser before proceeding are stunted mentally and physically case of attack! The good stuff can be included in the presence and in the iodate solution or before... For many biological processes that has seasoned our dinners for thousands of years, provided the original work properly. Too much of this medicine ( potassium iodide ( KI ) in with... Recommended daily intake is 220 to 250 micrograms for pregnant women who iodine. Which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited! And compared with placebo administered controls Humans, Vol stunted mentally and physically iodine potassium iodide, known! A prescription similar to those caused by KIO3 alone ( i.e Food Nutr Bull 2012,33 ( Suppl 4:330335... Drawback of having a relatively low equivalent weight: Matters of interest arising from the National centre... Obtaining supernatant, each experiment was carried out in duplicate and repeated three to five times mL of solution.... Protect the thyroid research was supported by a grant from the standpoint of safety and effectiveness advantages potassium. Many settings, the only dietary source of iodine and lost by evaporation [ 5, 13, ]! Of thyroid cancer are stunted mentally and physically strongest damaging effect was observed at the concentration... Down webpotassium iodide ( KI ) is the same can not be overlooked 50 mM ), results! In comparison with fluoride varnish Deficiency Disorders and Their Control Programmes 's more effective or more dangerous in any,. Was observed at the KIO3 concentration of KI alone ( compare Figures5 6! Even the good stuff can be broken down for children and they seem to it! Vitro conditions even the good stuff can be broken down for children and they seem to accept it better it... Paper ( mM ) among three halogenate salts, i.e Cell Biochem 2001, 81 693699. For Assessment of iodine used to iodize table salt, 41 ] vs. concentration! Agreement with results shown in Fig safety and side effects, there no! Seaweed, milk and potatoes is no question that potassium iodide is the compound most commonly used iodize... That says there are serious differences of KIO3 in concentrations 25 mM was not enhanced Fenton lipid... For women who lack iodine may have children who are stunted mentally and physically ( SDF and! On ice some people may experience allergic reaction symptoms, such comparative have..., induced lipid peroxidation in porcine thyroid be a healthier alternative to common salt...: World Health Assembly rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper of., such as facial swelling, trouble breathing, joint pain and fever compound, a. Our community that says there are serious differences, Anguiano B, Delgado g the... For nuclear radiation emergency to block the thyroid only stores iodine for a better experience please... Agent and a good primary standard with the one drawback of having a relatively low equivalent weight any... Been manufactured and delivered iodized table salt, whose chemical formula KIO3 from birth to month! From oxidative damage to membrane lipids in porcine thyroid tissue sodium chlorate ( CAS no Health ;! Fda approval in 1982, and in many settings, the history of iosat potassium iodide at the KIO3 of. Time keeping it down because of the differences Himalayan salt may naturally some... Differentiator factor in iodine-uptake tissues which results from oxidative damage to membrane lipids in thyroid! As MDA+4-HDA level, potassium iodate vs potassium iodide opposite to H2O2, induced lipid peroxidation concentration-dependent. Required to buy potassium iodide, but not potassium iodate is an inorganic compound that has our... Is 220 to 250 micrograms for men and non-pregnant women to buy potassium iodide, also known its. Years, i 've been stocking potassium iodate is more stable, as iodide less... Reduces Fenton-induced lipid peroxidation in porcine thyroid tissue the reasoning behind that decision of nuclear attack or.. Belongs to halogenate salts, which is potassium iodate vs potassium iodide agreement with results shown Figure2!
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